Real-world safety and decision help for new Alzheimer's treatments
Official title: Improving Informed Decision Making Through Real-World Safety Monitoring of New Alzheimer's Treatments
Funded at Hebrew Rehabilitation Center for Aged · NIH-11448523 · Data updated 2026-11-12
This grant looks at how monoclonal antibody drugs for Alzheimer’s affect people in real life and creates a practical decision aid for patients and families.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hebrew Rehabilitation Center for Aged NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $671,336 |
| NIH project number | 1R01AG094761-01A1 |
| Project ID | NIH-11448523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 65 and older who have or are considering monoclonal antibody therapy for Alzheimer’s disease.
✕Less likely to help
Individuals not considering or receiving monoclonal antibody therapy for Alzheimer’s may not directly benefit from the decision aid.
What this research studies
Many older adults with Alzheimer’s face complex choices about amyloid-targeting therapies because these drugs can slow symptoms but also cause serious risks and require ongoing testing. The project will use Medicare data and real-world electronic health records to understand the everyday treatment burden and safety concerns outside clinical trials. Researchers will combine findings with patient-facing tools to help people weigh benefits, risks, costs, and preferences before starting therapy. The work aims to support clearer, personalized decisions for patients and caregivers.
Why it matters
Potential benefit: Patients could have clearer, personalized guidance when considering these treatments, helping them balance benefits and risks.
How similar studies have gone: There is growing evidence on real-world safety of these therapies, but comprehensive decision aids in real-world settings are limited.
Where this research is happening
-
Hebrew Rehabilitation Center for Aged
Boston, United States Active
Researchers
- Principal investigator: Kim, Dae Hyun — Hebrew Rehabilitation Center for Aged
- Study coordinator: Kim, Dae Hyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.