READD-ADSP: Building a genetic resource to understand Alzheimer's risk in African, African American, and Hispanic/Latino groups
Official title: Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)
Funded at University of Miami School of Medicine · NIH-11563823 · Data updated 2026-11-12
This grant plans to create a large, shared genetic resource to study why Alzheimer's disease affects people of African, African American, and Hispanic/Latino ancestry differently and to help tailor future prevention and treatment efforts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $48,464 |
| NIH project number | 3U19AG074865-05S3 |
| Project ID | NIH-11563823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals of African, African American, or Hispanic/Latino ancestry who are either at risk for or affected by Alzheimer’s disease and related dementias, and who consent to genetic and clinical data collection.
✕Less likely to help
People not represented by African, African American, or Hispanic/Latino ancestry may not directly benefit from this resource in the short term.
What this research studies
Alzheimer's disease affects people across all backgrounds, but much of the genetic research has underrepresented some groups. This project will recruit and genotype 13,000 individuals, including participants from Africa, African Americans, and Hispanic/Latino communities, and harmonize their clinical data with existing studies. The effort will focus on how genetic ancestry and environment interact to influence disease risk, with two projects to demonstrate the resource's value. By creating this large, accessible dataset, researchers hope to uncover population-specific risk factors and improve our understanding of AD biology in diverse groups. The work will be conducted across multiple sites under the University of Miami system, with collaboration from national consortia.
Why it matters
Potential benefit: If successful, the resource could lead to more accurate risk predictions and personalized strategies for prevention and treatment of Alzheimer's disease in diverse populations.
How similar studies have gone: Previous multi-population genetic endeavors have shown that diverse datasets improve understanding of risk factors and can reveal ancestry-specific signals, though this project is among the larger, focused efforts in AD genomics.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Pericak-Vance, Margaret a. — University of Miami School of Medicine
- Study coordinator: Pericak-Vance, Margaret a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.