READD-ADSP: Building a genetic resource to study Alzheimer's in diverse populations
Official title: Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)
Funded at University of Miami School of Medicine · NIH-11563819 · Data updated 2026-11-12
A large, diverse group of people will be enrolled and studied to understand how genetics influence Alzheimer's disease across African, African American, and Hispanic/Latino populations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $49,529 |
| NIH project number | 3U19AG074865-05S2 |
| Project ID | NIH-11563819 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals of African, African American, or Hispanic/Latino ancestry who are or may be at risk for Alzheimer’s disease and related dementias and who are willing to contribute clinical data and genetic samples.
✕Less likely to help
Participants who do not have Alzheimer’s disease or a risk profile that aligns with the study’s ancestry-focused aims may not directly benefit from the findings.
What this research studies
This project will create a centralized genomics resource focused on Alzheimer’s disease in people with African and Hispanic/Latino ancestry, collecting clinical, phenotypic, and genetic data from 13,000 individuals. It aims to harmonize these data with existing AD genetics efforts to enable cross-study comparisons and deeper understanding of how ancestry and environment shape risk. Two hypothesis-driven projects will use the resource to illuminate genetic factors contributing to AD in these populations. Researchers will recruit participants, collect samples, genotype them, and integrate findings with broader AD genomic research to improve representation and discovery. The work is designed to advance knowledge that could eventually inform more personalized prevention and treatment strategies for diverse communities.
Why it matters
Potential benefit: If successful, this resource could lead to better understanding of AD risk in diverse populations and inform more inclusive approaches to prevention and therapy.
How similar studies have gone: Previous large-scale AD genetics projects have shown the value of multi-ancestry cohorts, but this effort emphasizes broader inclusion and data harmonization to enhance discovery.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Pericak-Vance, Margaret a. — University of Miami School of Medicine
- Study coordinator: Pericak-Vance, Margaret a.
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.