Radiomics analysis of brain MRIs from kids to help understand autism and related neurodevelopmental concerns
Official title: Radiomics for Clinically-Acquired Brain MRIs of Youth with Neurodevelopmental Disorders
Funded at Children's Hosp of Philadelphia · NIH-11370211 · Data updated 2026-11-12
A pediatric brain MRI study will look at imaging data from real patient scans to find patterns that could improve understanding of autism and other neurodevelopmental issues in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 8, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $758,427 |
| NIH project number | 5R01MH134896-03 |
| Project ID | NIH-11370211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and youths with neurodevelopmental concerns (e.g., autism spectrum features) whose clinically obtained brain MRIs are part of standard care.
✕Less likely to help
The study uses existing clinical scans; individual participants may not directly benefit from this analysis, but findings may improve future care.
What this research studies
This project uses routine clinical brain MRIs from children to build useful brain-structure measurements that can be compared across hospitals. By accounting for differences in MRI machines and sites, the team aims to create reliable benchmarks for brain development in kids with neurodevelopmental concerns. The goal is to combine imaging metrics with genetic and environmental information to better understand conditions like autism and related symptoms. Results could eventually help clinicians interpret pediatric brain scans more accurately and tailor care. Participation would involve using de-identified clinical imaging data and may inform future patient-centered research.
Why it matters
Potential benefit: If successful, the work could lead to better interpretation of pediatric brain scans and support more precise care decisions for children with neurodevelopmental concerns.
How similar studies have gone: Preliminary work on brain growth charts and clinical-benchmarking approaches has shown promise in imaging-based developmental assessment.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Alexander-Bloch, Aaron Felix — Children's Hosp of Philadelphia
- Study coordinator: Alexander-Bloch, Aaron Felix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.