Quick testing for antibiotic resistance in bacteria from blood samples
Official title: Rapid Antibiotic Susceptibility Testing via Selective Lysis and Nanogap Trapping
Funded at Univ of Maryland, College Park · NIH-11110065 · Data updated 2026-11-12
This study is working on a quick way to test how bacteria in your blood react to antibiotics, so doctors can make faster and better treatment decisions when you're sick.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project start | April 10, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $490,093 |
| NIH project number | 1R01AI190349-01 |
| Project ID | NIH-11110065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients presenting with acute bacterial infections who require timely antibiotic treatment.
✕Less likely to help
Patients with viral infections or those who do not require antibiotic therapy may not benefit from this research.
What this research studies
This research aims to develop a rapid method for testing how bacteria respond to antibiotics directly from blood samples. By using a microfluidic technology, the project will isolate bacteria from blood, identify the pathogens, and assess their susceptibility to antibiotics within 75 minutes. This approach seeks to overcome the limitations of current testing methods that are often too slow for timely treatment decisions, especially during critical early stages of infection. The goal is to provide clinicians with faster and more accurate information to guide antibiotic therapy, ultimately improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to faster and more effective treatment of bacterial infections, reducing complications and healthcare costs associated with antibiotic resistance.
How similar studies have gone: Other research has shown promise in rapid antibiotic susceptibility testing, but this specific approach using microfluidic technology is relatively novel.
Where this research is happening
-
Univ of Maryland, College Park
College Park, United States Active
Researchers
- Principal investigator: Devoe, Don L — Univ of Maryland, College Park
- Study coordinator: Devoe, Don L
Related research
Other NIH-funded projects on the same topics.
-
Understanding how fetal immobility changes tendon properties to prevent limb deformities
Researchers are studying why tendons in babies born with limited or no movement develop abnormally, aiming to improve treatments for limb deformities like arthrogryposis and clubfoot.
-
Stepped Care, Peer-Delivered Help for ART Adherence and Substance Use in Primary Care
A peer-delivered, stepped-care program in busy primary care clinics helps people living with HIV stay adherent to ART and address substance use, aiming to fit resources and improve outcomes.
-
Role of tryptophan breakdown and AHR in Leishmania resistance to antimony
This project looks at why a parasite that causes skin ulcers in South America may resist a common drug, by studying how human immune cells react to infection.
-
How home noise affects children's development
A study looking at how everyday sounds at home influence how young children learn language and pay attention.
-
Healthy Brain and Child Development study network
A nationwide effort to map how genes, environment, and experiences shape brain growth in thousands of babies and young kids from birth through age 10.
-
Time-varying brain connections to better understand concussion impacts
A researcher will develop and test new computational methods to map how brain regions talk to each other over time, with a focus on concussion-related changes, to better guide future treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.