Time-varying brain connections to better understand concussion impacts
Official title: Time-varying spatiotemporal causal interactions in the functional brain networks
Funded at Univ of Maryland, College Park · NIH-11473691 · Data updated 2026-11-12
A researcher will develop and test new computational methods to map how brain regions talk to each other over time, with a focus on concussion-related changes, to better guide future treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $82,377 |
| NIH project number | 3R00NS123113-04S1 |
| Project ID | NIH-11473691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with concussion or vestibular syndrome who can undergo brain imaging and related assessments.
✕Less likely to help
Individuals without concussion or without access to the required imaging and clinical evaluations may not benefit.
What this research studies
This project uses advanced math and computer modeling to study how signals move between brain areas during and after a concussion. The team will apply multimodal brain imaging data to build time-sensitive models of brain connectivity, including how long signals last and how much information they carry. A deep learning component will aim to predict how patients might respond to therapies based on these brain dynamics. The work will move from method development to clinical relevance by focusing on disorders like vestibular syndrome that commonly follow concussion. The overall goal is to translate computational insights into better understanding and treatment of brain injuries.
Why it matters
Potential benefit: If successful, the research could improve how clinicians predict and tailor treatments for concussion-related brain dysfunction.
How similar studies have gone: Previous work demonstrated the feasibility of time-varying brain connectivity models, with growing evidence supporting their relevance to concussion-related deficits.
Where this research is happening
-
Univ of Maryland, College Park
College Park, United States Active
Researchers
- Principal investigator: Xu, Nan — Univ of Maryland, College Park
- Study coordinator: Xu, Nan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.