Protective role of MIRO1 in lung blood-vessel injury
Official title: Protective mechanisms in lung vascular injury
Funded at University of Rochester · NIH-11447485 · Data updated 2026-11-12
A study at the University of Rochester will explore how a protein called MIRO1 helps lung blood vessels stay intact during severe lung injury, with the goal of guiding new therapies for people with ALI/ARDS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $717,611 |
| NIH project number | 1R01HL184442-01A1 |
| Project ID | NIH-11447485 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with severe lung injury/ARDS and related inflammatory conditions could benefit from therapies targeting endothelial MIRO1.
✕Less likely to help
People without lung injury or those not suitable for endothelial-targeted therapies may not benefit.
What this research studies
This project looks at how endothelial cells lining the lung's blood vessels stay healthy when injury occurs, aiming to keep the vessel barrier strong. Researchers will examine MIRO1, a mitochondrial protein, and how its presence supports endothelial function and healing in models of ALI/ARDS. They plan to test whether increasing MIRO1 in lung vessels can reduce leaks and improve recovery after injury. The work combines basic biology with experiments that model human lung injury to identify potential therapeutic strategies. If successful, these findings could lay the groundwork for new treatments to lessen mortality from severe respiratory failure.
Why it matters
Potential benefit: If MIRO1 helps protect the lung barrier, patients with ALI/ARDS could experience fewer complications and better recovery.
How similar studies have gone: Previous work suggests mitochondrial Rho GTPases like MIRO1 influence endothelial barrier function, but translating this to therapy is still being explored.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Rahman, Arshad — University of Rochester
- Study coordinator: Rahman, Arshad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.