PRMT inhibitors as a new approach for ovarian and breast cancer

Who could benefit from this research

What this research studies

This project looks at how blocking protein arginine methyltransferases (PRMTs) could complement existing therapies for ovarian and breast cancers. It combines large-scale drug screening and cancer genomics to identify effective combination strategies with PRMT inhibitors. The goal is to understand the mechanisms by which PRMT inhibitors work in these cancers and to translate that knowledge into better treatment options for patients. The work is led by the University of Pennsylvania and aims to move findings toward clinical relevance in conditions with poor prognosis.

Why it matters

Where this research is happening

• University of Pennsylvania
  Philadelphia, United States Active

Researchers

• Principal investigator: Zhang, Lin — University of Pennsylvania
• Study coordinator: Zhang, Lin

Related research

Other NIH-funded projects on the same topics.

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• Genomic study to understand how genetics and epigenetics shape triple-negative breast cancer in African ancestry

  This study looks at how inherited genes and gene activity affect triple-negative breast cancer in people of African ancestry to better understand why outcomes can be worse.

  NIH research Tuskegee University · Tuskegee Institute, United States · NIH-11621786

• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

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  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11608792

• Linking heavy metal exposure to a tougher breast cancer type (TNBC)

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  NIH research University of Louisville · Louisville, United States · NIH-11567535

• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

  Researchers will study how dormant cancer cells in liver and skin metastases of triple-negative breast cancer become quiescent or wake up, using organ-on-chip models and single-cell analysis to map chromatin states.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.