Preventing vision loss in Multiple Sclerosis by targeting a specific enzyme
Official title: Targeting spermine oxidase to prevent vision loss in Multiple Sclerosis
Funded at Charlie Norwood VA Medical Center · NIH-10948933 · Data updated 2026-11-12
This study is looking at how a substance called Spermine Oxidase (SMOX) might be causing vision problems in people with Multiple Sclerosis (MS), and it hopes to find new ways to help protect your eyesight from damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Charlie Norwood VA Medical Center NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | October 1, 2021 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX005193-04 |
| Project ID | NIH-10948933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Multiple Sclerosis who are experiencing vision problems.
✕Less likely to help
Patients with other neurological conditions unrelated to Multiple Sclerosis may not benefit from this research.
What this research studies
This research investigates the role of Spermine Oxidase (SMOX) in causing neurodegeneration in the retinas of patients with Multiple Sclerosis (MS). The study aims to understand how increased levels of SMOX lead to oxidative damage and vision impairment. By exploring the molecular mechanisms involved, the research seeks to identify new therapeutic targets that could help prevent vision loss associated with MS. Patients may benefit from potential new treatments that address the neurodegenerative aspects of their condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent vision loss in patients with Multiple Sclerosis.
How similar studies have gone: While targeting neurodegeneration in MS is a relatively novel approach, there is growing evidence that similar strategies may improve outcomes in other neurodegenerative diseases.
Where this research is happening
-
Charlie Norwood VA Medical Center
Augusta, United States Active
Researchers
- Principal investigator: Narayanan, Priya — Charlie Norwood VA Medical Center
- Study coordinator: Narayanan, Priya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.