PrEP delivery strategies to boost HIV prevention in Botswana
Official title: Evaluation of PrEP implementation strategies for the general population in Botswana
Funded at University of Botswana · NIH-11352677 · Data updated 2026-11-12
A large study in Botswana tests community-based ways to get more people to start and keep using PrEP to prevent HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Botswana NIH-funded |
| Lab location | 1 site (Gaborone, Botswana) |
| Project start | August 5, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $645,004 |
| NIH project number | 5R01MH134784-03 |
| Project ID | NIH-11352677 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in Botswana who are at risk for HIV and are considering or already using PrEP.
✕Less likely to help
Individuals not at risk for HIV or those not interested in PrEP may not benefit.
What this research studies
This project will try multiple, culturally tailored community approaches to deliver PrEP and keep people on it. It will measure how well these strategies work in real-world health settings and how easily they can be put into practice. The goal is to find scalable, cost-effective methods that could also inform similar efforts in the U.S. South and other high HIV-burden areas.
Why it matters
Potential benefit: If successful, the study could highlight practical ways to increase PrEP uptake and persistence, reducing new HIV infections.
How similar studies have gone: Previous demonstrations of differentiated service delivery have shown promise in improving PrEP use in various settings, though results vary by context.
Where this research is happening
-
University of Botswana
Gaborone, Botswana Active
Researchers
- Principal investigator: Mosepele, Mosepele — University of Botswana
- Study coordinator: Mosepele, Mosepele
Related research
Other NIH-funded projects on the same topics.
-
mChoice: Boosting PrEP Use and Adherence for Black and Latino MSM with Tailored Training and Support
A national study to help Black and Latino men who have sex with men start and stick with PrEP through culturally matched provider training and patient support.
-
Harnessing male peer networks to boost HIV testing and PrEP use
A large clinical trial in South Africa tests whether giving HIV self-test kits through male peer networks, with phone support, increases PrEP uptake among men.
-
Harnessing men's peer networks to boost HIV self-testing and PrEP use
A large project in South Africa tests whether giving HIV self-test kits through men’s social networks, with phone support, can lead to more men starting PrEP and using HIV testing.
-
Participatory system dynamics to improve PrEP access in the Bronx
A community-driven project in the Bronx will use system dynamics to identify practical ways to help people at risk for HIV start and stay on PrEP.
-
TB PrEP: Bringing HIV prevention to households affected by TB in Uganda
Aims to help people in households with TB in Uganda access HIV PrEP as part of a combined prevention approach.
-
CARES: A practical program to help adolescent girls and young women use PrEP in Africa
A program called CARES helps young women in South Africa and Zimbabwe use different PrEP options better, with counseling, reminders, and options for support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.