Precursors of Stroke Incidence and Prognosis
Funded at Boston University Medical Campus · NIH-11393354 · Data updated 2026-11-12
This grant explores how life-long vascular risk factors and stroke-related brain changes influence the risk of cognitive problems, including Alzheimer’s-type dementia, in diverse adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 1981 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,459,367 |
| NIH project number | 5R01NS017950-41 |
| Project ID | NIH-11393354 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with history of stroke or at risk for stroke, and those from diverse racial backgrounds who participate in large cohort studies.
✕Less likely to help
Individuals without vascular risk factors, stroke history, or willingness to engage in long-term cohort studies may see limited direct benefit.
What this research studies
If funded, researchers will use large, long-term health studies to map how obesity, cholesterol, and other vascular risks affect brain health over time. They plan to build and test tools that predict PS-VCID risk at different life stages and across racial groups. The project emphasizes collaboration with large cohorts to understand causal links and potential prevention strategies that could delay or reduce dementia after stroke. The goal is to inform personalized and public health approaches to preserve brain health.
Why it matters
Potential benefit: Better prediction and prevention strategies for dementia risk related to stroke and vascular factors in diverse populations.
How similar studies have gone: Previous large-cohort analyses have linked vascular risk factors to cognitive decline, but comprehensive, multimodal risk prediction tools across diverse groups are still needed.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Romero, Jose Rafael — Boston University Medical Campus
- Study coordinator: Romero, Jose Rafael
Related research
Other NIH-funded projects on the same topics.
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Personalized stroke risk prediction for atrial fibrillation patients using advanced data and models
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What leads to stroke and how it affects thinking and memory
This project uses long-term heart and blood vessel health information to find who is more likely to have thinking problems or dementia after a stroke, focusing on Black and White adults.
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Improving stroke risk prediction for patients with atrial fibrillation.
This study is working on a new tool to help predict stroke risk for people with atrial fibrillation by looking at both health and social factors, so that doctors can better tailor prevention strategies just for you.
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Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria
A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
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Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
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Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.