Precision tapering of dupilumab in asthma for safer, cost-saving interval extension
Official title: 1/2 Precision Tapering of Biologic Therapy in Asthma: Identifying Predictors of Successful Dupilumab Interval Extension
Funded at National Jewish Health · NIH-11436814 · Data updated 2026-11-12
We’re testing if adults with well-controlled asthma on dupilumab can safely extend the time between injections to reduce costs and burden.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | September 15, 2026 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,099,722 |
| NIH project number | 1UG3HL188699-01 |
| Project ID | NIH-11436814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with asthma who are well controlled on dupilumab plus controller therapy.
✕Less likely to help
Patients with unstable asthma or adverse reactions to dupilumab may not benefit from tapering.
What this research studies
If you have severe asthma and are already doing well on dupilumab, this study will test longer intervals between doses to see if control is still good. In a two-period trial, participants will either keep dosing every two weeks or switch to every four weeks for 48 weeks, and then those still on the study will have a second randomization to explore longer gaps up to every eight weeks. Researchers will look at clinical outcomes and also try to identify biomarkers that predict who can taper successfully. The goal is to determine safe, effective, and affordable dosing tailored to individual patients. Participation would require regular visits and monitoring while on dupilumab therapy.
Why it matters
Potential benefit: If successful, the study could support safer, lower-cost dupilumab dosing guidelines for patients with well-controlled asthma.
How similar studies have gone: This approach builds on prior work showing possible safety of interval extension in select patients but requires confirmation in a rigorous randomized trial.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Wechsler, Michael E — National Jewish Health
- Study coordinator: Wechsler, Michael E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.