Orchestrating intestinal immunity through microbiota and CX3CR1+ cells
Official title: Orchestrating intestinal immunity through microbiota-CX3CR1+ cell interactions
Funded at Sloan-Kettering Inst Can Research · NIH-11387465 · Data updated 2026-11-12
This grant explores how gut microbes interact with specific immune cells to support healthy immunity and prevent inflammatory gut problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 2, 2017 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $531,000 |
| NIH project number | 5R01AI125264-09 |
| Project ID | NIH-11387465 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory bowel disease or other inflammatory gut conditions, and individuals interested in future microbiome-immune therapies.
✕Less likely to help
There may be no direct benefit for healthy individuals without inflammatory gut conditions.
What this research studies
Researchers will study how signals from gut bacteria influence intestinal immune cells, aiming to understand how homeostasis is maintained and how dysbiosis can lead to inflammatory diseases like inflammatory bowel disease. They will use a mix of lab experiments and animal models to see how certain E. coli strains trigger IL-1b production and how this affects macrophages and T cells in the gut. The work seeks to map the steps from microbial signals to immune outcomes, with the goal of finding new ways to restore balance in inflammatory conditions. Findings could point toward targeted therapies that modulate microbiota-immune interactions to protect the intestinal barrier.
Why it matters
Potential benefit: If successful, this research could inform new approaches to prevent or treat inflammatory gut diseases by modulating microbiota-immune interactions.
How similar studies have gone: Previous studies have linked microbiota-driven signals to immune regulation, with promising but intermediate results guiding translational approaches.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Diehl, Gretchen E — Sloan-Kettering Inst Can Research
- Study coordinator: Diehl, Gretchen E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.