Nucleotide Support to Help Heart Cells Heal After a Heart Attack
Official title: Therapeutic Potential of Nucleotide Supplementation in Cardiac Repair
Funded at Beckman Research Institute/city of Hope · NIH-11425650 · Data updated 2026-11-12
A research project will test whether giving specific nucleotides can boost heart muscle cells to grow and repair after a heart attack in animal models and larger animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 1, 2026 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $813,810 |
| NIH project number | 1R01HL187416-01 |
| Project ID | NIH-11425650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with ischemic heart disease or a history of myocardial infarction in the context of future clinical translation, once safety and efficacy are demonstrated.
✕Less likely to help
Patients without heart damage or those not progressing to repair after myocardial infarction may not benefit from this foundational research.
What this research studies
This project aims to understand how balancing cellular nucleotides affects the ability of heart cells to proliferate after ischemic injury. Researchers will study nucleotide supplementation as a potential therapy to promote repair of damaged heart tissue in animals, including large-animal models, to better mimic human biology. The work builds on lab findings showing nucleotide levels influence cell growth and oxidative stress, with the goal of translating these insights to therapies that improve heart function after infarction.
Why it matters
Potential benefit: If successful, this approach could lead to new treatments that help the heart repair damaged tissue and improve outcomes after a heart attack.
How similar studies have gone: Preliminary cell culture data suggest nucleotide treatments can increase cardiomyocyte proliferation, but results in animal models are still being established.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Wang, Zhao — Beckman Research Institute/city of Hope
- Study coordinator: Wang, Zhao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.