Novel macrophage repolarization therapy for colorectal cancer
Funded at Panorama Research, INC. · NIH-11314230 · Data updated 2026-11-12
A new treatment approach aims to reshape the immune cells in colorectal cancer to help the body fight the disease, especially for patients who don’t have a strong response to current immunotherapies.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Panorama Research, INC. NIH-funded |
| Lab location | 1 site (Sunnyvale, United States) |
| Project start | September 25, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $387,240 |
| NIH project number | 1R43CA310345-01 |
| Project ID | NIH-11314230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with colorectal cancer, particularly those not benefiting from current immunotherapies, could be considered in future trials.
✕Less likely to help
The therapy may not benefit patients whose tumors do not rely on macrophage-driven immune suppression or who cannot tolerate immune-modulating treatments.
What this research studies
This project targets the tumor microenvironment in colorectal cancer by changing the behavior of macrophages that can suppress or support immune responses. By repolarizing these cells, the therapy hopes to enable a more effective attack on cancer cells when used alongside existing immunotherapies. The work will involve preclinical studies in animal models to understand how the macrophages respond and how the treatment could fit with current treatment strategies. If successful, it could lead to new options for patients with advanced or non- MSI colorectal cancer who currently have limited durable responses.
Why it matters
Potential benefit: If successful, patients may experience better responses to combination immunotherapies and improved long-term control of colorectal cancer.
How similar studies have gone: Previous work suggests macrophage repolarization can alter tumor immunity, but applying it to colorectal cancer is an emerging and promising area.
Where this research is happening
-
Panorama Research, INC.
Sunnyvale, United States Active
Researchers
- Principal investigator: Larrick, James W — Panorama Research, INC.
- Study coordinator: Larrick, James W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.