Nitrated oleic acid helps brain blood vessels grow and aid recovery after stroke
Official title: Nitrated oleic acid-mediated angiogenesis and long-term functional recovery after ischemic stroke
Funded at Veterans Health Administration · NIH-11403592 · Data updated 2026-11-12
A study exploring a natural compound (OA-NO2) that may boost new blood vessel growth and improve long-term recovery after an ischemic stroke, with patients who have experienced stroke in mind.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | October 1, 2026 |
| Project end | September 30, 2030 |
| Funding year | 2026 |
| NIH project number | 1I01RD001388-01A2 |
| Project ID | NIH-11403592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21 years and older) who have experienced an ischemic stroke and are potential candidates for therapies that promote brain angiogenesis.
✕Less likely to help
Some individuals may not respond to OA-NO2 or may have contraindications to this treatment.
What this research studies
This project tests whether nitro-oleic acid can promote brain blood vessel growth after a stroke and support better functional recovery. It combines human-relevant approaches with animal models to understand how OA-NO2 interacts with brain tissue and its potential to improve blood flow and healing. If successful, the work could point toward new therapies that extend beyond the current treatment window for stroke. The study is led by the Veterans Health Administration at the Pittsburgh site, focusing on veterans and other adults affected by stroke.
Why it matters
Potential benefit: If successful, OA-NO2 could become a new treatment strategy to enhance brain repair and improve daily functioning after stroke.
How similar studies have gone: Preclinical evidence in mouse models suggests OA-NO2 can improve neurobehavioral outcomes after stroke, with early human studies needed to confirm safety and efficacy.
Where this research is happening
-
Veterans Health Administration
Pittsburgh, United States Active
Researchers
- Principal investigator: Yin, Kejie — Veterans Health Administration
- Study coordinator: Yin, Kejie
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.