Next-gen single-molecule protein sequencing for cancer profiling
Official title: Next-Generation Oncoproteomic Sequencing and Precision Profiling
Funded at Electronic Biosciences, INC. · NIH-11352939 · Data updated 2026-11-12
A new single-molecule protein sequencing platform aims to directly read cancer-related proteins with ultra-high accuracy and through- put to reveal variants and modifications.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Electronic Biosciences, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | June 8, 2026 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $418,854 |
| NIH project number | 1R21CA304932-01A1 |
| Project ID | NIH-11352939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with cancer or at-risk populations whose tumors could be profiled using advanced proteomic techniques.
✕Less likely to help
Patients without access to proteomics-enabled diagnostics may not directly benefit in the short term.
What this research studies
This grant funds the development of a new technology that can sequence individual proteins directly, repeatedly, to achieve detailed maps of protein variants and post-translational modifications in cancer. The approach builds on nanopore sequencing ideas to gain high sensitivity and throughput, potentially overcoming current proteomics limits. If successful, it could yield precise protein-level information that complements DNA sequencing and helps guide personalized cancer care.
Why it matters
Potential benefit: Patients could benefit from more precise cancer profiling, leading to better-targeted therapies and a clearer understanding of tumor biology.
How similar studies have gone: Previous proteomics efforts improved protein detection, but this platform aims for direct single-molecule sequencing with ultra-precision.
Where this research is happening
-
Electronic Biosciences, INC.
San Diego, United States Active
Researchers
- Principal investigator: Peterson, Eric Mayo — Electronic Biosciences, INC.
- Study coordinator: Peterson, Eric Mayo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.