Developing a new method for sequencing proteins using enzymes
Official title: Direct Proteolytic Machine Assessments for Unfolding and Sequencing Proteins
Funded at Electronic Biosciences, INC. · NIH-11179965 · Data updated 2026-11-12
This study is working on a new way to read proteins one at a time, which could help doctors get better information about diseases and improve tests for patients, especially for those with rare or complicated proteins.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Electronic Biosciences, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | June 5, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $350,000 |
| NIH project number | 1R43GM159820-01 |
| Project ID | NIH-11179965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve low-abundance proteins or complex protein modifications, which are often challenging to diagnose.
✕Less likely to help
Patients with conditions that do not involve protein sequencing or those who do not have low-abundance proteins may not benefit from this research.
What this research studies
This research focuses on creating a novel enzyme-based system for sequencing proteins at the single-molecule level. By addressing the limitations of current proteomic tools, the project aims to enhance the accuracy and efficiency of protein sequencing, particularly for low-abundance proteins and those with complex modifications. Patients may benefit from improved diagnostic capabilities and a better understanding of diseases through more comprehensive proteomic analysis. The approach combines advanced bioinformatics with innovative enzymatic processing to achieve high throughput and precision.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and cost-effective diagnostic tools for various diseases.
How similar studies have gone: While the approach is innovative, similar enzyme-based sequencing methods have shown promise in preliminary studies, indicating potential for success.
Where this research is happening
-
Electronic Biosciences, INC.
San Diego, United States Active
Researchers
- Principal investigator: German, Sean — Electronic Biosciences, INC.
- Study coordinator: German, Sean
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.