Developing a new method for sequencing proteins using enzymes
Direct Proteolytic Machine Assessments for Unfolding and Sequencing Proteins
This study is working on a new way to read proteins one at a time, which could help doctors get better information about diseases and improve tests for patients, especially for those with rare or complicated proteins.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Electronic Biosciences, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-11179965 on NIH RePORTER |
What this research studies
This research focuses on creating a novel enzyme-based system for sequencing proteins at the single-molecule level. By addressing the limitations of current proteomic tools, the project aims to enhance the accuracy and efficiency of protein sequencing, particularly for low-abundance proteins and those with complex modifications. Patients may benefit from improved diagnostic capabilities and a better understanding of diseases through more comprehensive proteomic analysis. The approach combines advanced bioinformatics with innovative enzymatic processing to achieve high throughput and precision.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve low-abundance proteins or complex protein modifications, which are often challenging to diagnose.
Not a fit: Patients with conditions that do not involve protein sequencing or those who do not have low-abundance proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and cost-effective diagnostic tools for various diseases.
How similar studies have performed: While the approach is innovative, similar enzyme-based sequencing methods have shown promise in preliminary studies, indicating potential for success.
Where this research is happening
San Diego, United States
- Electronic Biosciences, INC. — San Diego, United States (Active)
Researchers
- Principal investigator: German, Sean — Electronic Biosciences, INC.
- Study coordinator: German, Sean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.