Developing advanced RNA sequencing technologies to understand gene expression and modifications.
Official title: SpinSeq
Funded at Electronic Biosciences, INC. · NIH-11178898 · Data updated 2026-11-12
This study is working on new ways to read RNA directly, which helps us see how genes work and how changes in RNA can affect our cells, making it easier to understand diseases and improve treatments.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Electronic Biosciences, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | June 6, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $383,482 |
| NIH project number | 1R43HG014419-01 |
| Project ID | NIH-11178898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to gene expression and RNA modifications, which may include various genetic disorders and cancers.
✕Less likely to help
Patients with conditions unrelated to RNA biology or those who do not have genetic disorders may not receive direct benefits from this research.
What this research studies
This research focuses on improving RNA sequencing technologies to better understand how genes are regulated and how RNA modifications affect cellular functions. By developing methods that allow for direct RNA sequencing without converting it to complementary DNA, the project aims to preserve critical RNA modifications that are often lost in traditional methods. This could lead to more accurate detection and quantification of RNA modifications, enhancing our understanding of various biological processes and disease mechanisms. The project seeks to address the challenges posed by high error rates and complex RNA structures in current sequencing technologies.
Why it matters
Potential benefit: If successful, this research could lead to more accurate insights into gene regulation and RNA modifications, potentially improving diagnosis and treatment strategies for various diseases.
How similar studies have gone: While RNA sequencing technologies have been widely used, this specific approach to direct RNA sequencing without cDNA conversion is relatively novel and aims to overcome existing limitations.
Where this research is happening
-
Electronic Biosciences, INC.
San Diego, United States Active
Researchers
- Principal investigator: Peterson, Amberlyn Megan — Electronic Biosciences, INC.
- Study coordinator: Peterson, Amberlyn Megan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.