New technology to study bladder function and disorders
Official title: Precision-cut bladder slices: an enabling technology for urologic research
Funded at Boston Children's Hospital · NIH-10785220 · Data updated 2026-11-12
This study is looking at tiny slices of bladder tissue to learn how bladder muscles work in both healthy and sick people, with the hope of finding better treatments for bladder problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $337,284 |
| NIH project number | 1R21DK138394-01 |
| Project ID | NIH-10785220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with bladder disorders, as well as healthy volunteers for comparative analysis.
✕Less likely to help
Patients with conditions unrelated to bladder function or those who are not eligible for tissue sampling may not benefit from this research.
What this research studies
This research focuses on developing precision-cut bladder slices to better understand how bladder muscles function in both healthy and diseased states. By creating thin slices of bladder tissue, researchers can analyze how these tissues contract and relax, as well as their stiffness, in a way that closely mimics the natural environment of the bladder. This innovative approach aims to provide insights that could lead to improved treatments for bladder disorders. The research will involve both healthy and diseased human bladder tissues, allowing for a comprehensive evaluation of bladder function.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for bladder disorders, improving patient outcomes.
How similar studies have gone: Previous research using similar precision-cut tissue slice technology has shown success in other organs, indicating potential for this novel approach in bladder research.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Adam, Rosalyn M — Boston Children's Hospital
- Study coordinator: Adam, Rosalyn M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.