New methods to find small molecules that interact with proteins
Official title: Novel platforms for the discovery of bioactive small molecules
Funded at University of Florida · NIH-11014463 · Data updated 2026-11-12
This study is exploring new ways to find tiny molecules that can help control proteins in our cells, which could lead to new treatments for aging and diseases, and it's designed for anyone interested in how we can improve health through better drug development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $565,112 |
| NIH project number | 5R35GM151875-02 |
| Project ID | NIH-11014463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from degenerative diseases or conditions related to aging.
✕Less likely to help
Patients with acute conditions unrelated to protein regulation or aging may not benefit from this research.
What this research studies
This research focuses on developing innovative techniques to discover small molecules that can bind to proteins, particularly those involved in the Ubiquitin Proteasome System, which is essential for protein regulation in cells. By using DNA-encoded library technology, the researchers will create libraries of these small molecules on tiny beads and screen them with labeled proteins to identify potential drug leads. The goal is to find new compounds that can help manipulate the proteasome, which may lead to treatments for aging and degenerative diseases. Additionally, the research aims to create a new class of drugs that can directly target proteins for degradation without needing prior modification.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for aging-related conditions and degenerative diseases by improving protein regulation in cells.
How similar studies have gone: Other research has successfully utilized DNA-encoded library technology for drug discovery, indicating a promising approach in this area.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Kodadek, Thomas J. — University of Florida
- Study coordinator: Kodadek, Thomas J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.