New imaging technique for studying tissue function using x-rays
Official title: Cherenkov Excited Luminescence Metabolic Sensing (CELMS)
Funded at University of Wisconsin-Madison · NIH-11000353 · Data updated 2026-11-12
This study is testing a new imaging method that uses special x-rays to see how well tissues in the body are working, which could help doctors better understand and track health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | December 12, 2023 |
| Project end | May 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $299,239 |
| NIH project number | 5R01EB033877-02 |
| Project ID | NIH-11000353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may require advanced imaging techniques for metabolic assessment.
✕Less likely to help
Patients who are under 21 years old or those who do not require metabolic imaging may not benefit from this research.
What this research studies
This research develops a novel imaging technique called Cherenkov Excited Luminescence Metabolic Sensing (CELMS), which utilizes high-energy x-rays from a linear accelerator to excite optical molecular probes deep within tissues. By employing this method, researchers aim to achieve high-resolution imaging of small molecule tracers that indicate tissue function in living organisms. The technique allows for imaging through several centimeters of tissue while maintaining high molecular sensitivity and spatial resolution. This could lead to better understanding and monitoring of metabolic processes in various tissues.
Why it matters
Potential benefit: If successful, this research could significantly enhance the ability to monitor and understand metabolic processes in tissues, potentially leading to improved diagnostics and treatment strategies for various conditions.
How similar studies have gone: While this approach is innovative, similar imaging techniques have shown promise in other contexts, suggesting potential for success in this novel application.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Pogue, Brian William — University of Wisconsin-Madison
- Study coordinator: Pogue, Brian William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.