Neuroinflammation and Alzheimer’s biomarkers: how they change together over time
Official title: Temporal Associations of Neuroinflammation with Alzheimer’s Disease Biomarkers and Cognition
Funded at Mayo Clinic Rochester · NIH-11427255 · Data updated 2026-11-12
This project studies how brain inflammation relates to Alzheimer’s biomarkers and memory changes over the course of the disease, to help predict progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 30, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $677,880 |
| NIH project number | 1R01AG102933-01 |
| Project ID | NIH-11427255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults across the Alzheimer’s disease spectrum, including those with amyloid positive and negative status and varying cognitive levels.
✕Less likely to help
Individuals not in the Alzheimer’s spectrum or those unwilling to undergo PET imaging or long-term follow-up may see little or no direct benefit.
What this research studies
Researchers will track neuroinflammation, amyloid, tau, and cognitive performance in people across the Alzheimer’s disease spectrum over several years. They will use PET imaging and blood tests to see how inflammation changes alongside biomarkers and thinking skills. By comparing baseline measurements and how these markers evolve, they aim to identify whether neuroinflammation can predict progression and how this relationship varies with disease stage. This could guide timing for potential anti-inflammatory therapies in the future.
Why it matters
Potential benefit: If successful, the work could improve how we predict Alzheimer’s progression and inform when anti-inflammatory approaches might be most helpful.
How similar studies have gone: Previous AD research suggests inflammatory processes are linked to disease progression, but temporal relationships are still being clarified.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Cogswell, Petrice M. — Mayo Clinic Rochester
- Study coordinator: Cogswell, Petrice M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.