Neuroanatomy core for brain mapping and imaging tools
Official title: C4: Neuroanatomy
Funded at Princeton University · NIH-11385526 · Data updated 2026-11-12
A research collaboration at Princeton is testing how memory and decision-making emerge from brain networks using advanced brain-imaging tools and standardized data pipelines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | August 8, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $415,428 |
| NIH project number | 5U19NS132720-04 |
| Project ID | NIH-11385526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with interest in brain research or patients contributing brain tissue or imaging data through collaboration networks; no direct patient participation is described in the core activities.
✕Less likely to help
Patients not contributing imaging data or brain tissue may not directly benefit from these core tools.
What this research studies
This project provides cutting-edge neuroanatomy tools and standardized software to map brain connections and activity during learning. It uses light-sheet microscopy with viral tracers, whole-brain imaging, and advanced electron microscopy to study where and how neurons interact. The work includes automated image processing, brain registration to a standard atlas, transcriptional profiling, and ongoing refinement of sample prep and sectioning methods to support large-scale brain mapping.
Why it matters
Potential benefit: If successful, the work could enable clearer maps of brain circuits involved in memory and decision-making, informing future treatments for cognitive disorders.
How similar studies have gone: Previous work showed that advanced brain-mapping pipelines can reveal how learning alters brain connectivity, with ongoing enhancements.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Wang, Samuel Sheng-Hung — Princeton University
- Study coordinator: Wang, Samuel Sheng-Hung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.