How neuropeptides could influence aging and Alzheimer’s risk
Official title: Reprogramming organismal lifespan through modulation of neuropeptides
Funded at Princeton University · NIH-11539228 · Data updated 2026-11-12
Researchers at Princeton are studying whether changing brain signaling chemicals called neuropeptides can extend healthy aging and reduce Alzheimer’s-related brain changes, with a focus on people at risk for Alzheimer’s disease dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | September 1, 2026 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00AG078499-03 |
| Project ID | NIH-11539228 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals at risk for Alzheimer’s disease dementia or those who have early cognitive concerns related to aging.
✕Less likely to help
People without an interest in aging biology or Alzheimer’s disease risk may not directly benefit from this basic science work.
What this research studies
This project uses a short-lived vertebrate model, the African killifish, to test whether removing or altering specific neuropeptides changes lifespan and healthspan, including brain aging. By linking neuropeptide activity to aging and neurodegeneration, the study aims to identify signals that shape long-term brain health. The work will involve genetic or molecular manipulation and careful monitoring of aging markers and cognitive-like outcomes in the model organism, with results informing potential human relevance. Findings could guide future approaches to delay or modify neurodegenerative processes in Alzheimer’s disease dementia.
Why it matters
Potential benefit: If successful, this research could reveal new biological targets to delay aging and reduce risk or progression of Alzheimer’s disease dementia in humans.
How similar studies have gone: Previous research has linked neuropeptides to brain aging and neurodegeneration, suggesting potential relevance but the exact impact on lifespan and disease progression remains to be proven.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Bedbrook, Claire Nicole — Princeton University
- Study coordinator: Bedbrook, Claire Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.