Nebulized NO-releasing therapy for Pseudomonas infections in bronchiectasis
Official title: Nebulized ALX1 as a treatment for Pseudomonas aeruginosa infections in bronchiectasis patients
Funded at Vast Therapeutics, INC. · NIH-11250047 · Data updated 2026-11-12
A new inhaled nitric oxide–releasing treatment is being tested to help people with bronchiectasis who have lung infections from Pseudomonas bacteria.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vast Therapeutics, INC. NIH-funded |
| Lab location | 1 site (Morrisville, UNITED STATES) |
| Project start | December 20, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2026 |
| Award (this year) | $988,594 |
| NIH project number | 5R44AI184225-02 |
| Project ID | NIH-11250047 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with bronchiectasis and a history of Pseudomonas aeruginosa infections.
✕Less likely to help
Patients without bronchiectasis or without Pseudomonas infections may not benefit from this approach.
What this research studies
Bronchiectasis can cause damaged airways and chronic lung infections, especially from Pseudomonas aeruginosa. This project explores a nitric oxide–releasing formulation delivered through the lungs to kill bacteria directly at the infection site. The study includes preclinical and early clinical development steps to understand how the drug behaves in the body and how it reaches the lungs. If successful, it could lead to more effective infection control with less harm to patients’ lungs.
Why it matters
Potential benefit: If successful, patients could experience better control of lung infections and slower decline in lung function.
How similar studies have gone: Early non-human and human data suggest inhaled NO–releasing therapies can reduce lung bacteria and inflammation, but clinical effectiveness in bronchiectasis is still being established.
Where this research is happening
-
Vast Therapeutics, INC.
Morrisville, United States Active
Researchers
- Principal investigator: Stasko, Nathan Allan — Vast Therapeutics, INC.
- Study coordinator: Stasko, Nathan Allan
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.