Mutant IDH glioma: how blocking IDH and DNA damage affects tumor growth
Official title: Molecular Mechanisms of Mutant IDH inhibition and DNA Damage in IDH-mutant Glioma
Funded at Massachusetts General Hospital · NIH-11397550 · Data updated 2026-11-12
A patient-friendly look at a grant testing how stopping mutant IDH enzymes and DNA damage pathways could slow or stop certain brain cancers in adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 20, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $412,500 |
| NIH project number | 5DP5OD039431-02 |
| Project ID | NIH-11397550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with IDH-mutant glioma or related advanced brain tumors who could benefit from improved targeted therapies in future trials.
✕Less likely to help
Patients with non-IDH-mutant gliomas or those not eligible for mIDH-directed therapies may not experience direct benefit.
What this research studies
This project uses a specially engineered mouse model that mimics human IDH-mutant glioma to study how mutant IDH inhibitors work in real tumors. It focuses on understanding the cellular changes and vulnerabilities that occur when the mutant IDH enzyme is blocked, including effects on DNA and replication. The work aims to identify combinations or strategies that enhance the effectiveness of IDH inhibitors in treating glioma. The research leverages preclinical models to inform future clinical testing and potential patient benefit.
Why it matters
Potential benefit: If successful, the findings could guide better treatment strategies for adults with IDH-mutant gliomas and bring more effective options closer to clinical use.
How similar studies have gone: Previous models suggest IDH inhibitors can be effective in some contexts, but responses vary and improved models are needed to translate findings to patients.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Shi, Diana — Massachusetts General Hospital
- Study coordinator: Shi, Diana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.