Multiregion Brain Interactions in Decision Making
Official title: P4: Multiregion interactions
Funded at Princeton University · NIH-11385509 · Data updated 2026-11-12
Researchers at Princeton are testing how multiple brain regions communicate during decision-making to understand the timing and content of information flow.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | August 8, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $622,272 |
| NIH project number | 5U19NS132720-04 |
| Project ID | NIH-11385509 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with conditions affecting brain function involved in decision-making who could benefit from future therapies informed by understanding brain network dynamics.
✕Less likely to help
Healthy individuals or those without involvement in related brain-network studies may not directly benefit.
What this research studies
This project will record activity from many brain regions at once and study how their signals move between areas during decision tasks. They will use advanced recording tools to capture detailed cellular-level data and apply new computational methods to map time-varying information transfer. In addition, they will perform targeted experiments in the basal ganglia using cell-type–specific perturbations to see how non-selective activity can still bias choices. The goal is to link which regions communicate when task demands change and how this shapes decisions.
Why it matters
Potential benefit: If successful, the work could reveal how brain networks coordinate decisions, potentially guiding new approaches for treating disorders that affect decision-making.
How similar studies have gone: Previous studies have shown meaningful insights from multi-region recordings, and this project expands on that with larger-scale data and perturbations.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Witten, Ilana — Princeton University
- Study coordinator: Witten, Ilana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.