Multimorbid pediatric atopic and airway diseases: prenatal exposures and placental epigenetics
Official title: Epidemiology of multimorbid pediatric atopic and airway diseases and the impact of prenatal maternal environmental exposures and placental epigenetics
Funded at Henry Ford Health System · NIH-11362476 · Data updated 2026-11-12
This study follows a group of children to understand how early environmental exposures before birth and placental biology relate to multiple allergic and airway conditions in kids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health System NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $651,213 |
| NIH project number | 5UH3OD035518-04 |
| Project ID | NIH-11362476 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children in or around infancy to 11 years old who are part of the CANOE cohort or similar atopic risk groups, with access to placental tissue data and relevant environmental exposure information.
✕Less likely to help
Children without atopic risk factors or without access to the study's environmental and epigenetic data may not directly benefit.
What this research studies
The project continues the CANOE cohort from Henry Ford Health System to explore why some children develop several allergic and airway diseases, such as eczema, food allergy, asthma, and allergic rhinitis. It will examine prenatal environmental factors and DNA methylation in placental tissue to identify possible early biomarkers for high-risk children. Researchers plan to map how demographic differences influence the occurrence of multiple atopic conditions and their impact on growth and development. The work leverages long-term follow-up data and biospecimen analysis to uncover pathways that might inform early prevention or targeted interventions.
Why it matters
Potential benefit: If successful, findings could help identify children at risk for multiple allergic diseases early and guide preventive strategies and personalized care.
How similar studies have gone: Previous cohorts have linked prenatal exposures and placental epigenetics to later atopic outcomes, though comprehensive multimorbidity phenotypes are still being clarified.
Where this research is happening
-
Henry Ford Health System
Detroit, United States Active
Researchers
- Principal investigator: Straughen, Jennifer K. — Henry Ford Health System
- Study coordinator: Straughen, Jennifer K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.