Multimodal genetic regulation in coronary artery disease
Official title: Multimodal genetic regulatory architecture of coronary artery disease
Funded at University of Virginia · NIH-11393320 · Data updated 2026-11-12
A research grant using advanced genetic and cellular analyses to understand what drives coronary artery disease in diverse populations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | June 1, 2019 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $682,043 |
| NIH project number | 5R01HL148239-08 |
| Project ID | NIH-11393320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for atherosclerotic cardiovascular disease, especially from diverse ancestries, may benefit from advances arising from this research.
✕Less likely to help
People without CAD risk factors or those not contributing samples or data would not directly benefit.
What this research studies
This project studies how genes and regulatory elements control the cells in the walls of arteries involved in CAD. It uses state-of-the-art single-cell and chromatin profiling to map how genetic variation influences disease-related cell states in coronary arteries. The work builds on a large bank of tissue samples from people of different ancestries to connect genetic signals with cellular changes that lead to atherosclerosis. Findings could point to new targets for therapies by revealing which cell types and regulatory switches matter most in CAD. The study will combine bulk and single-cell data analysis to pinpoint mechanisms across diverse populations.
Why it matters
Potential benefit: Understanding the genetic and cellular drivers of CAD could lead to personalized prevention and treatment strategies.
How similar studies have gone: Previous studies have linked genetic variation to CAD risk, and single-cell approaches have started to uncover regulatory mechanisms, with promising but early findings.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Miller, Clint L — University of Virginia
- Study coordinator: Miller, Clint L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.