Endothelial cell pathways to tackle coronary artery disease
Official title: Project 1: Endothelial cell programs for coronary artery disease
Funded at Stanford University · NIH-11391257 · Data updated 2026-11-12
A patient-facing look at a project studying blood vessel cells to uncover new ideas for treating coronary artery disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $825,603 |
| NIH project number | 5P01HL180323-02 |
| Project ID | NIH-11391257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for coronary artery disease may benefit from future therapies developed from this work.
✕Less likely to help
People not related to CAD risk or not eligible for future trials may not receive direct benefit.
What this research studies
This project uses cutting-edge genetics in human endothelial cells to map which genes drive coronary artery disease. By testing many CAD-related genes at once, researchers hope to find key pathways that can be targeted with new therapies. They will also explore how these pathways interact with endothelial function and blood flow to influence disease risk. The work involves advanced lab approaches in human cells and in living models to understand how to translate findings into treatments.
Why it matters
Potential benefit: If successful, the research could identify new targets for drugs or therapies to reduce heart disease risk.
How similar studies have gone: This approach builds on prior work showing that many CAD risk genes act through a few common pathways, with promising early results.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Gupta, Rajat M — Stanford University
- Study coordinator: Gupta, Rajat M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.