Multi-omics gut health with stool cells sequencing
Official title: Development of fecal exfoliome sequencing as a multi-omics approach for gut health management
Funded at Foli Bio INC. · NIH-11314303 · Data updated 2026-11-12
A new stool-based test called Foli-seq aims to map gut health by analyzing host genes and other molecular data from exfoliated cells in stool.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Foli Bio INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 18, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $399,875 |
| NIH project number | 1R43HG014430-01A1 |
| Project ID | NIH-11314303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals interested in non-invasive GI health monitoring may participate, especially those seeking insights into their gut gene activity.
✕Less likely to help
People without interest in stool-based testing or who have conditions unrelated to gut transcriptomics may not benefit.
What this research studies
This project develops a non-invasive way to study gut health by extracting and sequencing RNA and other molecular signals from cells shed into stool. It focuses on expanding the transcriptome coverage and adding genomic and epi-transcriptome layers to create a robust gut health profile. If successful, it could support personalized monitoring of GI health and disease risk using a simple stool sample.
Why it matters
Potential benefit: If successful, it could provide a non-invasive, comprehensive way to monitor gut health and detect early signals of GI issues.
How similar studies have gone: Other stool-based omics approaches have shown promise in reflecting GI biology, but this specific multi-omics stool RNA platform is still exploratory.
Where this research is happening
-
Foli Bio INC.
New York, United States Active
Researchers
- Principal investigator: Huang, Yiming — Foli Bio INC.
- Study coordinator: Huang, Yiming
Related research
Other NIH-funded projects on the same topics.
-
Two volumes of human milk to support growth and gut health in very preterm babies
A multicenter trial will compare two amounts of human milk given to very preterm infants to see which supports better growth and gut health.
-
How gut bacteria-derived purines affect gut health and disease
This study is looking at how a substance made by gut bacteria called hypoxanthine helps keep your gut healthy, focusing on how it affects energy use, protects the gut lining, and helps heal wounds, so we can learn more about the important role of gut bacteria in your overall health.
-
Investigating the effects of a milk protein on infant gut health and immunity
This study is looking at ways to make infant formula healthier by adding a special protein found in breast milk that helps babies' tummies and immune systems, using a new method that’s better for the environment, so that more babies can benefit from safer and more nutritious formula.
-
Gut health follow-along with Peachbiotic in adults
This single-arm study tests whether Peachbiotic taken daily for 12 weeks helps adults with gut symptoms feel better.
-
IgG Binding Protein LT for gut health during travel
This study tests whether IgG Binding Protein LT helps healthy adults maintain gut health while traveling internationally.
-
Overnight Temperature Regulation to Test Gut Health, Inflammation, and Circadian Rhythms
This study tests whether two weeks of using the Eight Sleep Pod at night can improve gut bacteria balance, lower inflammation, and strengthen daily temperature and blood pressure rhythms in postmenopausal women and age-matched men with poor sleep.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.