How gut bacteria-derived purines affect gut health and disease
Microbiota-sourced purines in gut health and disease
['FUNDING_CAREER'] · UNIVERSITY OF COLORADO DENVER · NIH-10892928
This study is looking at how a substance made by gut bacteria called hypoxanthine helps keep your gut healthy, focusing on how it affects energy use, protects the gut lining, and helps heal wounds, so we can learn more about the important role of gut bacteria in your overall health.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10892928 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific purine metabolite, hypoxanthine, produced by gut bacteria in maintaining gut health. It explores how this metabolite influences the metabolism of intestinal cells, particularly in energy balance, barrier function, and wound healing. The study employs various experimental approaches, including the use of genetically modified E. coli to assess the impact of microbiota-derived hypoxanthine on gut health. By understanding these mechanisms, the research aims to uncover new insights into how gut bacteria contribute to overall intestinal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal disorders or those interested in gut health.
Not a fit: Patients without any gastrointestinal issues or those not interested in gut health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving gut health and treating related diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in health, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, JOSEPH SCOTT — UNIVERSITY OF COLORADO DENVER
- Study coordinator: LEE, JOSEPH SCOTT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.