MRI parameters that reveal tissue makeup and structure
Official title: TRD 3: MRI parameters reflecting tissue composition and microstructure
Funded at Hugo W. Moser Res Inst Kennedy Krieger · NIH-11334986 · Data updated 2026-11-12
This grant funds advanced MRI techniques to measure tissue composition and structure in humans, with the goal of improving how we understand tissue health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $162,346 |
| NIH project number | 2P41EB031771-06 |
| Project ID | NIH-11334986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults undergoing MRI as part of research studies or clinical care who consent to advanced imaging procedures.
✕Less likely to help
Some patients may not benefit if they cannot undergo MRI or if the biomarkers do not translate to clinical outcomes.
What this research studies
This project develops MRI pulse sequences to capture information about water content, relaxation, exchange, and magnetic properties that reflect tissue makeup like myelin and iron. By combining different imaging methods, researchers aim to generate quantitative imaging biomarkers that help assess tissue status and response to treatment. The work is conducted by a team led by Peter van Zijl and colleagues at a major imaging institute. It focuses on noninvasive imaging that could someday inform clinical decisions for patients with nervous system and related conditions.
Why it matters
Potential benefit: If successful, these MRI biomarkers could improve diagnosis, monitoring, and treatment planning for patients with conditions affecting brain and tissue structure.
How similar studies have gone: Previous work in quantitative MRI has shown promise in reflecting tissue properties, but translation to routine care requires further validation.
Where this research is happening
-
Hugo W. Moser Res Inst Kennedy Krieger
Baltimore, United States Active
Researchers
- Principal investigator: Van Zijl, Peter Cm — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Van Zijl, Peter Cm
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.