Microvascular brain blood flow and CSF cleaning in Lewy body dementia
Official title: Interaction between microvascular function and CSF clearance in Lewy body dementia
Funded at Hugo W. Moser Res Inst Kennedy Krieger · NIH-11463249 · Data updated 2026-11-12
A non-invasive MRI study in people with Alzheimer's-related dementias will explore how tiny blood vessel pulsations affect brain fluid clearance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $768,228 |
| NIH project number | 4R01AG082257-02 |
| Project ID | NIH-11463249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Alzheimer's disease and related dementias who can undergo MRI scanning and participate in imaging studies.
✕Less likely to help
People who cannot safely undergo MRI or are not suitable for this imaging protocol may not benefit.
What this research studies
This project uses advanced MRI methods to look at how microvascular pulsatility and CSF clearance interact in the brains of people with dementia. The researchers aim to image multiple brain systems in the same subjects and relate these findings to memory and thinking abilities. Results could help explain how blood flow and brain waste removal relate to disease features like amyloid and tau. The study will build on prior work to validate imaging methods against tissue studies to better interpret MRI signals in patients. If successful, the work could pave the way for new imaging biomarkers in ADRD research.
Why it matters
Potential benefit: If successful, the research could lead to better imaging biomarkers that help diagnose ADRD earlier and track disease progression.
How similar studies have gone: Previous work suggests that microvascular and lymphatic changes can be detected non-invasively in dementia, but human in vivo data linking these systems is limited.
Where this research is happening
-
Hugo W. Moser Res Inst Kennedy Krieger
Baltimore, United States Active
Researchers
- Principal investigator: Hua, Jun — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Hua, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.