CEST imaging of muscle energy in heart failure patients
Official title: CEST Imaging of Regional Skeletal Muscle Energetics and the Relationship with Exercise Intolerance in Heart Failure
Funded at Hugo W. Moser Res Inst Kennedy Krieger · NIH-11444251 · Data updated 2026-11-12
A heart-failure study tests a new MRI method to map how muscles use energy during exercise in adults with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2020 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $811,485 |
| NIH project number | 2R01HL149742-05A1 |
| Project ID | NIH-11444251 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with diagnosed heart failure who can safely undergo MRI and exercise testing.
✕Less likely to help
Individuals unable to have MRI scans or participate in exertion-based assessments may not benefit from this study.
What this research studies
This project will use advanced MRI techniques to visualize how the skeletal muscles in adults with heart failure manage energy during and after exercise. By comparing creatine and phosphocreatine dynamics with muscle fatigue, it aims to identify noninvasive markers of muscle energy health. The findings could help doctors better understand why exercise intolerance occurs and eventually guide personalized treatment strategies. Participants may undergo MRI scans and light exercise protocols to assess muscle energy changes.
Why it matters
Potential benefit: If successful, the study could lead to better diagnosis and monitoring of muscle energy problems in heart failure, informing targeted therapies to improve exercise tolerance.
How similar studies have gone: Previous work suggests muscle energy metabolism is linked to fatigue in heart conditions, but noninvasive mapping with CEST MRI is a newer approach that requires validation.
Where this research is happening
-
Hugo W. Moser Res Inst Kennedy Krieger
Baltimore, United States Active
Researchers
- Principal investigator: Xu, Jiadi — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Xu, Jiadi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.