Molecular clues to heart risk and resilience in chronic coronary artery disease
Official title: Molecular predictors of cardiovascular events and resilience in chronic coronary artery disease
Funded at New York University School of Medicine · NIH-11332855 · Data updated 2026-11-12
Researchers will look at molecular markers to better predict heart attack risk and resilience in people with chronic CAD, using advanced data from large heart disease studies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $730,988 |
| NIH project number | 5R01HL165208-04 |
| Project ID | NIH-11332855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic coronary artery disease or those at risk of CAD who have or could contribute molecular data and follow-up cardiovascular outcomes.
✕Less likely to help
Patients without CAD or without access to the study data and follow-up may not experience direct benefits.
What this research studies
This project aims to uncover molecular features that explain why some people with chronic CAD have higher event risk while others show resilience. By using a multi-omics approach and data from landmark trials, the study seeks to improve risk prediction beyond current models. The work will connect biological markers with cardiovascular outcomes to guide personalized treatment decisions for patients with CAD. RESULTS could help clinicians tailor therapies based on an individual’s molecular risk and protective factors. The research involves analysis of existing patient data, labs, and adjudicated cardiovascular events managed at NYU School of Medicine and collaborators.
Why it matters
Potential benefit: If successful, patients with CAD could receive more precise risk assessments and personalized treatment plans to prevent future heart events.
How similar studies have gone: Prior omics studies in CAD show promise in identifying risk and resilience markers, suggesting potential for meaningful advancement here.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Newman, Jonathan D — New York University School of Medicine
- Study coordinator: Newman, Jonathan D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.