Modulating splanchnic nerves to improve heart failure symptoms
Official title: Splanchnic Nerve Modulation In Heart Failure (Splanchnic X)
Funded at Duke University · NIH-11118680 · Data updated 2026-11-12
This study is looking at how blocking certain nerve signals might help people with heart failure feel better and be more active, especially those with a specific type of heart issue, and it aims to find out who could benefit the most from this treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $590,884 |
| NIH project number | 5R01HL171305-02 |
| Project ID | NIH-11118680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have heart failure with reduced ejection fraction.
✕Less likely to help
Patients with heart failure who do not have reduced ejection fraction or those with other significant comorbidities may not benefit from this research.
What this research studies
This research investigates how blocking signals from the splanchnic nerves can help patients with heart failure, particularly those with reduced ejection fraction. The study will involve prolonged nerve blockade to assess its effects on cardiovascular health and physical activity. Researchers will use advanced imaging techniques to visualize the splanchnic nerves and understand how this intervention can alleviate symptoms of heart failure. By identifying which patients benefit most from this approach, the research aims to improve treatment outcomes for heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve the quality of life for heart failure patients.
How similar studies have gone: Preliminary studies have shown promising results with similar nerve modulation approaches, indicating potential for success in this research.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Fudim, Marat — Duke University
- Study coordinator: Fudim, Marat
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.