Modular bioluminescence imaging platform with a new multi-aperture method
Official title: A modular bioluminescence imaging platform using a novel multi-aperture method
Funded at In Vivo Analytics, INC. · NIH-11384484 · Data updated 2026-11-12
A new imaging platform using multiple views and a unique mirror system aims to greatly improve live tracking of disease processes in small animal models.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | In Vivo Analytics, INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 2, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $907,050 |
| NIH project number | 5R44MH140129-03 |
| Project ID | NIH-11384484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are researchers and labs using small animal models to study human diseases where non-invasive imaging informs treatment development.
✕Less likely to help
Direct patient participation is not part of this preclinical imaging grant, so patients would not be enrolled in this study.
What this research studies
This grant supports developing an advanced bioluminescence imaging system that works better for detecting signals from deep or weak targets in small animals. The project introduces a modular imaging platform with a concentric mirror and stray-light collimator to enable multi-view, 3D tomography and better anatomical alignment. It usesBody-Conforming Animal Molds and Organ Probability Maps to provide instant anatomical context and automated, reproducible measurements. The goal is to make bioluminescence imaging more sensitive, accurate, and user-friendly for preclinical disease research.
Why it matters
Potential benefit: If successful, patients could benefit indirectly through faster, more reliable preclinical research that informs safer and more effective therapies.
How similar studies have gone: Previous bioluminescence imaging work has shown value, but this project emphasizes a novel multi-aperture approach for improved sensitivity and 3D localization.
Where this research is happening
-
In Vivo Analytics, INC.
New York, United States Active
Researchers
- Principal investigator: Klose, Alexander D. — In Vivo Analytics, INC.
- Study coordinator: Klose, Alexander D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.