Metal-dependent protein phosphatases in Parkinson’s disease
Official title: Metal-dependent Protein Phosphatases as Key Regulators of Neurodegeneration in Parkinson’s disease
Funded at University of Wisconsin Milwaukee · NIH-11444650 · Data updated 2026-11-12
A study to understand how a family of brain enzymes called phosphatases may protect neurons in people with Parkinson’s disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin Milwaukee NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 22, 2026 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $576,455 |
| NIH project number | 1R15NS151713-01 |
| Project ID | NIH-11444650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Parkinson’s disease or individuals at risk due to related genetic factors, under study procedures appropriate for PD research.
✕Less likely to help
People without Parkinson’s disease or related risk factors may not benefit from this specific research.
What this research studies
Parkinson’s disease slowly damages brain cells that control movement. This project focuses on a group of enzymes (PPM1/ phosphatases) that could counteract harmful changes caused by disease-related proteins. Researchers will explore how these phosphatases influence neuron health and identify ways they might be leveraged to slow progression. The findings could point toward new strategies to protect brain cells in PD patients.
Why it matters
Potential benefit: If successful, the work could guide new treatments that help preserve movement and brain function in people with PD.
How similar studies have gone: Earlier work suggests phosphatases can modulate disease-related protein changes, but the exact role in PD protection is still being clarified.
Where this research is happening
-
University of Wisconsin Milwaukee
Milwaukee, United States Active
Researchers
- Principal investigator: Tran, an-Phu — University of Wisconsin Milwaukee
- Study coordinator: Tran, an-Phu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.