Metabolic Rescue Approach for Heart Failure
Official title: Metabolic Resuscitation in Heart Failure.
Funded at Texas A&m University Health Science Ctr · NIH-11385352 · Data updated 2026-11-12
This project looks at a new metabolic mechanism that could help the heart regain energy and function in people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $719,531 |
| NIH project number | 5R01HL176015-03 |
| Project ID | NIH-11385352 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with heart failure or those carrying genetic factors related to heart energy metabolism who may participate in future trials or biomarker studies.
✕Less likely to help
People without heart failure or without involvement in metabolic heart energy pathways may not benefit.
What this research studies
Heart failure happens when the heart cannot keep up with energy needs. researchers will study a newly identified metabolic resuscitation system that may be downregulated in heart disease, using animal models and genetic approaches to understand its role. the team will test whether manipulating this system can improve heart energy production and identify potential biomarkers to guide future therapies. results could point to new strategies to prevent progression and improve quality of life for those living with heart failure.
Why it matters
Potential benefit: If successful, the research could lead to new approaches to restore heart energy and slow or reverse heart failure progression.
How similar studies have gone: Previous work shows that energy metabolism is linked to heart failure, and novel metabolic targets have shown promise in early studies, though this exact system is still under investigation.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Chang, Jiang — Texas A&m University Health Science Ctr
- Study coordinator: Chang, Jiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.