Metabolic DNA Damage and Obesity-Linked Prostate Cancer Progression

Who could benefit from this research

What this research studies

This project looks at why obesity and high blood sugar may worsen prostate cancer by focusing on a harmful metabolic byproduct called methylglyoxal and its DNA damage. Researchers will examine how MG-related DNA lesions influence tumor growth and response to therapies, using data from tumors with aggressive prostate cancer and laboratory models. They plan to study a key DNA repair enzyme, APE1, and how its suppression by MG could promote mutagenesis and progression. The goal is to uncover mechanisms that could lead to new strategies for preventing progression and guiding treatment in patients with obesity-related prostate cancer.

Why it matters

Where this research is happening

• Beckman Research Institute/city of Hope
  Duarte, United States Active

Researchers

• Principal investigator: Shuck, Sarah C. — Beckman Research Institute/city of Hope
• Study coordinator: Shuck, Sarah C.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.