Memory-like NK cell therapy for AML relapse after transplant

Who could benefit from this research

What this research studies

This project aims to translate new immune insights into early-phase immunotherapy trials for AML patients who relapse after allogeneic transplant. It builds on the idea that memory-like NK cells can provide a rapid anti-leukemia effect and may support donor T cells to sustain disease control. The approach uses cytokine-activated memory-like NK cells derived from donors, tested for safety and potential effectiveness in relapsed AML post-transplant. Prior early-phase data suggested safety with signals of AML responses, guiding a continued exploration in this high-need population. The grant supports clinical trial development, translational studies, and monitoring of immune responses to understand how best to harness GVL effects while avoiding excessive toxicity.

Why it matters

Where this research is happening

• Washington University
  Saint Louis, United States Active

Researchers

• Principal investigator: Fehniger, Todd a — Washington University
• Study coordinator: Fehniger, Todd a

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.