Mediators of Muscle Rejuvenation with Aging
Funded at University of Arkansas at Fayetteville · NIH-11322087 · Data updated 2026-11-12
This research will look at how a key gene (MYC) in muscle cells responds to exercise and whether boosting it can promote muscle health and aging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $521,300 |
| NIH project number | 5R01AG080047-04 |
| Project ID | NIH-11322087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient enrollment; findings may guide future human studies on aging and muscle health.
✕Less likely to help
This study does not involve enrolling people; its results may not directly benefit current patients.
What this research studies
As we age, our muscles don’t work as well, and exercise may help reverse some of that decline. This project uses mouse models to turn MYC on in skeletal muscle and to measure how exercise and MYC together affect muscle function, energy use, and cell biology over time. Researchers will analyze gene activity in muscle fibers, study DNA methylation patterns, and track how these changes relate to aging and response to exercise. The goal is to understand if activating MYC in muscle could mimic exercise benefits and enhance aging resilience.
Why it matters
Potential benefit: If successful, this work could inform strategies to preserve or restore muscle function during aging.
How similar studies have gone: Prior work shows exercise-induced molecular changes in muscle; this study tests a targeted MYC mechanism in aging muscle.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Murach, Kevin — University of Arkansas at Fayetteville
- Study coordinator: Murach, Kevin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.