Measuring how kidneys transport salt using advanced imaging techniques
Official title: Measuring kidney NaCl transport in vivo with genetically encoded sensors
Funded at Wayne State University · NIH-11035602 · Data updated 2026-11-12
This study is looking at how kidneys control salt and water, which is important for keeping us healthy, especially for people with kidney problems or high blood pressure, by using special mice to see how these processes work in real time.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 6, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $400,820 |
| NIH project number | 1R21DK142082-01 |
| Project ID | NIH-11035602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic kidney disease, hypertension, or diabetes-related kidney issues.
✕Less likely to help
Patients with acute kidney injury or those not experiencing chronic kidney conditions may not benefit from this research.
What this research studies
This research focuses on understanding how kidneys manage salt and water balance, which is crucial for preventing diseases like chronic kidney disease and hypertension. The team will develop genetically modified mice that express special sensors to measure salt transport in live kidneys using advanced imaging techniques. By observing these processes at the single-cell level, researchers aim to gain insights into kidney function and its regulation. This innovative approach could lead to better understanding and treatment of kidney-related health issues.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for kidney diseases and related cardiovascular conditions.
How similar studies have gone: Previous research has shown promise in using genetically encoded sensors for monitoring cellular processes, indicating potential success for this novel approach.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Ortiz, Pablo a. — Wayne State University
- Study coordinator: Ortiz, Pablo a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.