Measuring brain connections using advanced genomic tools
High-throughput measurement of neuronal projections and synapses using Synapse-seq
This study is exploring new ways to look at how brain cells connect with each other, which could help us understand changes in these connections that happen in conditions like Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10640361 on NIH RePORTER |
What this research studies
This research focuses on developing innovative genomic tools, known as Synapse-seq, to measure and analyze the complex connections between neurons in the brain. By utilizing advanced techniques such as viral delivery of barcoded mRNA and single-cell sequencing, the project aims to quantify neuronal projections and synaptic connections in living organisms. This approach will allow researchers to better understand the structural basis of brain function and how these connections may be altered in conditions like Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's or those without any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of Alzheimer's disease and potentially identify new therapeutic targets.
How similar studies have performed: Previous research has shown promise in using genomic tools to study neural connectivity, indicating that this approach may yield valuable insights.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Macosko, Evan Z — Broad Institute, INC.
- Study coordinator: Macosko, Evan Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.