Matching exercise programs to Veterans with knee osteoarthritis
Official title: Precision Medicine Approach to Exercise-Based Interventions for Veterans with Knee Osteoarthritis
Funded at Durham VA Medical Center · NIH-10907442 · Data updated 2026-11-12
This study is looking to find the best exercise programs for Veterans with knee osteoarthritis by using personalized approaches, so each person can get the right kind of workout to help reduce pain and improve movement.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Durham VA Medical Center NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2023 |
| Project end | February 28, 2025 |
| Funding year | 2025 |
| NIH project number | 5I21HX003575-02 |
| Project ID | NIH-10907442 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans diagnosed with knee osteoarthritis who are seeking effective exercise-based treatment options.
✕Less likely to help
Patients who do not have knee osteoarthritis or those who are not Veterans may not receive any benefit from this research.
What this research studies
This research focuses on improving exercise-based interventions for Veterans suffering from knee osteoarthritis (OA) by using a precision medicine approach. It aims to identify which types of exercise programs are most effective for individual patients based on their unique characteristics. By analyzing data through advanced machine learning techniques, the study seeks to enhance the effectiveness and efficiency of care provided to Veterans. The goal is to ensure that each patient receives the most suitable exercise intervention to alleviate pain and improve function.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective exercise treatments for Veterans with knee osteoarthritis, significantly improving their quality of life.
How similar studies have gone: This research is innovative and represents a novel approach, as there is currently no existing evidence guiding the matching of exercise interventions to individual patient characteristics in this population.
Where this research is happening
-
Durham VA Medical Center
Durham, United States Active
Researchers
- Principal investigator: Allen, Kelli D. — Durham VA Medical Center
- Study coordinator: Allen, Kelli D.
Related research
Other NIH-funded projects on the same topics.
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Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
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Nanoparticles delivering an sPLA2 blocker for knee osteoarthritis
This project uses tiny, drug-filled nanoparticles to deliver an sPLA2-blocking medicine into the knee to reduce inflammation and slow knee osteoarthritis in people with painful knee OA.
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Remote tai chi for knee OA in everyday care
A nationwide study will test remotely delivered tai chi for people with knee osteoarthritis to see if it helps pain and function when added to usual care.
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Sensory nerves and joint cells talk to each other in knee arthritis
This grant tests how nerve signals and joint cells interact in knee osteoarthritis, with a focus on CGRP pathways and how they affect pain and joint damage.
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From knee to brain: a whole-body look at inflammation in knee osteoarthritis
Aims to map inflammation across the body and brain in people with knee osteoarthritis using advanced imaging to help explain and improve pain and treatment.
-
Determinants of rapid knee osteoarthritis progression using radiograph features
A patient-friendly look at how knees with osteoarthritis may progress more quickly, using advanced X-ray measurements to identify who is at higher risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.