Mapping the cellular environments essential for lung development and disease
Decoding the Cellular Niches Critical for Lung Maturation and Pathogenesis
This study is looking at the tiny environments in our lungs that help them grow and work properly, especially in understanding conditions like bronchopulmonary dysplasia, so we can learn more about lung health and diseases.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10672958 on NIH RePORTER |
What this research studies
This research focuses on understanding the unique cellular environments, or niches, within the lungs that are crucial for their development and function. By examining these niches at a single-cell level, the team aims to identify how they contribute to both normal lung maturation and diseases such as bronchopulmonary dysplasia. The project employs advanced technologies like single-cell RNA sequencing and three-dimensional imaging to create detailed maps of these cellular niches in both healthy and diseased lung tissues. This comprehensive approach could lead to new insights into lung health and disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and neonates diagnosed with chronic lung diseases, particularly those affected by bronchopulmonary dysplasia.
Not a fit: Patients with lung conditions unrelated to the cellular niches being studied, or those who are adults, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic lung diseases in infants, enhancing their health outcomes.
How similar studies have performed: Other research has shown success in mapping cellular environments in various organs, suggesting that this approach could yield valuable insights for lung diseases as well.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Sun, Xin — University of California, San Diego
- Study coordinator: Sun, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.