Mapping the cellular environments essential for lung development and disease
Decoding the Cellular Niches Critical for Lung Maturation and Pathogenesis
This study is looking at the special areas in the lungs that help them grow and work properly, especially in babies with lung problems like bronchopulmonary dysplasia, to learn how these areas might affect lung health and disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10932692 on NIH RePORTER |
What this research studies
This research investigates the unique cellular environments, or niches, within the lungs that are crucial for their development and function. By using advanced techniques like single-cell RNA sequencing and three-dimensional imaging, the team aims to identify and compare these niches in both healthy and diseased lung tissues. This work focuses particularly on conditions affecting infants, such as bronchopulmonary dysplasia, and seeks to understand how these niches contribute to lung maturation and disease processes. Patients may benefit from insights gained into the cellular mechanisms underlying chronic lung diseases in neonates.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and neonates diagnosed with chronic lung diseases, particularly those affected by bronchopulmonary dysplasia.
Not a fit: Patients with lung diseases unrelated to the developmental processes being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and interventions for chronic lung diseases in infants.
How similar studies have performed: Other research has shown promise in understanding lung diseases through cellular mapping, indicating that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Sun, Xin — University of California, San Diego
- Study coordinator: Sun, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.