Mapping how neurons connect in real time
Official title: Real-time mapping of neuronal connectivity at a synapse resolution
Funded at Johns Hopkins University · NIH-10940679 · Data updated 2026-11-12
This study is all about looking at how brain cells connect and communicate with each other, using a cool new tool called SynapShot that lets us see these connections in action, which could help us find better ways to understand and treat brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 5, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $403,806 |
| NIH project number | 1R01NS138176-01 |
| Project ID | NIH-10940679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that affect synaptic function, such as epilepsy or autism spectrum disorders.
✕Less likely to help
Patients with purely psychiatric disorders without neurological components may not benefit from this research.
What this research studies
This research focuses on understanding the connections between neurons, known as synapses, which are crucial for brain function. By using advanced imaging techniques, the researchers aim to visualize the structure and dynamics of synapses in real time. They have developed a new technology called SynapShot, which allows for the observation of synaptic changes as they happen, providing insights into how neurons communicate and adapt. This could lead to a better understanding of various brain disorders and how to treat them.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain connectivity and lead to new treatments for neurological disorders.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to study synaptic plasticity, indicating that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Kwon, Hyungbae — Johns Hopkins University
- Study coordinator: Kwon, Hyungbae
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.